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Defining principles of combination drug mechanisms of action

Combination chemotherapies have been a mainstay in the treatment of disseminated malignancies for almost 60 y, yet even successful regimens fail to cure many patients. Although their single-drug components are well studied, the mechanisms by which drugs work together in clinical combination regimens...

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Bibliografiske detaljer
Main Authors: Pritchard, Justin R., Bruno, Peter M., Gilbert, Luke A., Capron, Kelsey L., Lauffenburger, Douglas A., Hemann, Michael T.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545813/
https://ncbi.nlm.nih.gov/pubmed/23251029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210419110
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