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Intramolecular arrangement of sensor and regulator overcomes relaxed specificity in hybrid two-component systems

Cellular processes require specific interactions between cognate protein partners and concomitant discrimination against noncognate partners. Signal transduction by classical two-component regulatory systems typically entails an intermolecular phosphoryl transfer between a sensor kinase (SK) and a c...

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Detalhes bibliográficos
Main Authors: Townsend, Guy E., Raghavan, Varsha, Zwir, Igor, Groisman, Eduardo A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545799/
https://ncbi.nlm.nih.gov/pubmed/23256153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212102110
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