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Intrinsic Negative Feedback Governs Activation Surge in Two-Component Regulatory Systems

PhoP and PhoQ comprise a two-component system in the bacterium Salmonella enterica. PhoQ is the sensor kinase/phosphatase that modifies the phosphorylation state of the regulator PhoP in response to stimuli. The amount of phosphorylated PhoP surges after activation, then declines to reach a steady-s...

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Bibliografiska uppgifter
Huvudupphovsmän: Yeo, Won-Sik, Zwir, Igor, Huang, Henry V., Shin, Dongwoo, Kato, Akinori, Groisman, Eduardo A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713471/
https://ncbi.nlm.nih.gov/pubmed/22325356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.12.027
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