Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition

During development, the hematopoietic lineage transits through hemogenic endothelium, but the signaling pathways effecting this transition are incompletely characterized. Although the Hedgehog (Hh) pathway is hypothesized to play a role in patterning blood formation, early embryonic lethality of mic...

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Detalhes bibliográficos
Main Authors: Kim, Peter Geon, Albacker, Colleen E., Lu, Yi-fen, Jang, Il-ho, Lim, Yoowon, Heffner, Garrett C., Arora, Natasha, Bowman, Teresa V., Lin, Michelle I., Lensch, M. William, De Los Angeles, Alejandro, Zon, Leonard I., Loewer, Sabine, Daley, George Q.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545793/
https://ncbi.nlm.nih.gov/pubmed/23236128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214361110
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