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M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth
Many cancer cells have increased rates of aerobic glycolysis, a phenomenon termed the Warburg effect. In addition, in tumors there is a predominance of expression of the M2 isoform of pyruvate kinase (PKM2). M2 expression was previously shown to be necessary for aerobic glycolysis and to provide a g...
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| Autores principales: | , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3545759/ https://ncbi.nlm.nih.gov/pubmed/23267074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212780110 |
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