M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth

Many cancer cells have increased rates of aerobic glycolysis, a phenomenon termed the Warburg effect. In addition, in tumors there is a predominance of expression of the M2 isoform of pyruvate kinase (PKM2). M2 expression was previously shown to be necessary for aerobic glycolysis and to provide a g...

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Bibliografiska uppgifter
Huvudupphovsmän: Cortés-Cros, Marta, Hemmerlin, Christelle, Ferretti, Stephane, Zhang, Juan, Gounarides, John S., Yin, Hong, Muller, Alban, Haberkorn, Anne, Chene, Patrick, Sellers, William R., Hofmann, Francesco
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2013
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545759/
https://ncbi.nlm.nih.gov/pubmed/23267074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212780110
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