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Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells
BACKGROUND: Due to the frequent dysregulation of the PI3K/AKT/mTOR signaling pathway, mTOR represents a suitable therapeutic target in hepatocellular carcinoma (HCC). However, emerging data from clinical trials of HCC patients indicate that mTOR inhibition by RAD001 (Everolimus) alone has only moder...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3545733/ https://ncbi.nlm.nih.gov/pubmed/23167739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-11-85 |
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