Combined Targeting of AKT and mTOR Inhibits Proliferation of Human NF1-Associated Malignant Peripheral Nerve Sheath Tumour Cells In Vitro but not in a Xenograft Mouse Model In Vivo

Persistent signalling via the PI3K/AKT/mTOR pathway is a major driver of malignancy in NF1-associated malignant peripheral nerve sheath tumours (MPNST). Nevertheless, single targeting of this pathway is not sufficient to inhibit MPNST growth. In this report, we demonstrate that combined treatment wi...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Schulte, Alexander, Ewald, Florian, Spyra, Melanie, Smit, Daniel J., Jiang, Wei, Salamon, Johannes, Jücker, Manfred, Mautner, Victor-Felix
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073166/
https://ncbi.nlm.nih.gov/pubmed/32102484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21041548
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