Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the sixth most common cancer, and the third most common cause of cancer related death worldwide. The multi-kinase inhibitor Sorafenib represents the only systemic treatment option until today, and results from clinical trials with allosteric mTOR inhibitors were sob...

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Publicado en:J Cancer
Autores principales: Ewald, Florian, Nörz, Dominik, Grottke, Astrid, Bach, Johanna, Herzberger, Christiane, Hofmann, Bianca T., Nashan, Björn, Jücker, Manfred
Formato: Artigo
Lenguaje:Inglês
Publicado: Ivyspring International Publisher 2015
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622849/
https://ncbi.nlm.nih.gov/pubmed/26535060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.12452
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