Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the sixth most common cancer, and the third most common cause of cancer related death worldwide. The multi-kinase inhibitor Sorafenib represents the only systemic treatment option until today, and results from clinical trials with allosteric mTOR inhibitors were sob...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Cancer
Egile Nagusiak: Ewald, Florian, Nörz, Dominik, Grottke, Astrid, Bach, Johanna, Herzberger, Christiane, Hofmann, Bianca T., Nashan, Björn, Jücker, Manfred
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Ivyspring International Publisher 2015
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622849/
https://ncbi.nlm.nih.gov/pubmed/26535060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.12452
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