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Molecular Effects of Familial Hypertrophic Cardiomyopathy-Related Mutations in the TNT1 Domain of cTnT

Familial hypertrophic cardiomyopathy (FHC) is one of the most common genetic causes of heart disease. Approximately 15% of FHC-related mutations are found in cTnT [cardiac troponin (cTn) T]. Most of the cTnT FHC-related mutations are in or flanking the N-tail TNT1 domain that directly interacts with...

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Bibliografiska uppgifter
Huvudupphovsmän: Manning, Edward P., Tardiff, Jil C., Schwartz, Steven D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545441/
https://ncbi.nlm.nih.gov/pubmed/22579624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.05.008
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