IMMUNOHISTOCHEMICAL LOSS OF SUCCINATE DEHYDROGENASE SUBUNIT A (SDHA) IN GASTROINTESTINAL STROMAL TUMORS (GISTS) SIGNALS SDHA GERMLINE MUTATION

A subset (7–10%) of gastric GISTs is notable for the immunohistochemical loss of succinate dehydrogenase (SDH) subunit B (SDHB), which signals the loss of function of the SDH-complex consisting of mitochondrial inner membrane proteins. These SDH-deficient GISTs are known to be KIT/PDGFRA wild type,...

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Detalhes bibliográficos
Main Authors: Miettinen, Markku, Killian, J. Keith, Wang, Zeng-Feng, Lasota, Jerzy, Lau, Christopher, Jones, Laura, Walker, Robert, Pineda, Marbin, Zhu, Yuelin Jack, Kim, Su Y, Helman, Lee, Meltzer, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545041/
https://ncbi.nlm.nih.gov/pubmed/23282968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAS.0b013e3182671178
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