Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor

Gastrointestinal stromal tumors (GIST) harbor driver mutations of signal transduction kinases such as KIT, or, alternatively, manifest loss-of-function defects in the mitochondrial succinate dehydrogenase (SDH) complex, a component of the Krebs cycle and electron transport chain. We have uncovered a...

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Autors principals: Killian, J. Keith, Kim, Su Young, Miettinen, Markku, Smith, Carly, Merino, Maria, Tsokos, Maria, Quezado, Martha, Smith, William I., Jahromi, Mona S., Xekouki, Paraskevi, Szarek, Eva, Walker, Robert L., Lasota, Jerzy, Raffeld, Mark, Klotzle, Brandy, Wang, Zengfeng, Jones, Laura, Zhu, Yuelin, Wang, Yonghong, Waterfall, Joshua J., O’Sullivan, Maureen J., Bibikova, Marina, Pacak, Karel, Stratakis, Constantine, Janeway, Katherine A., Schiffman, Joshua D., Fan, Jian-Bing, Helman, Lee, Meltzer, Paul S.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135374/
https://ncbi.nlm.nih.gov/pubmed/23550148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0092
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