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Mutants of Human αB-Crystallin Cause Enhanced Protein Aggregation and Apoptosis in Mammalian Cells: Influence of co-expression of HspB1

Mutations of human αB-crystallin cause congenital cataract and cardio-myopathy by protein aggregation and cell death. How mutations of αB-crystallin become pathogenic is poorly understood. To better understand the cellular events related to protein aggregation and cell death, we transfected cataract...

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Bibliografske podrobnosti
Main Authors: Raju, Ilangovan, Abraham, Edathara C.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544980/
https://ncbi.nlm.nih.gov/pubmed/23194663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.11.051
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