Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants

BACKGROUND: The SH2B1 gene (Src-homology 2B adaptor protein 1 gene) is a solid candidate gene for obesity. Large scale GWAS studies depicted markers in the vicinity of the gene; animal models suggest a potential relevance for human body weight regulation. METHODS: We performed a mutation screen for...

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Main Authors: Volckmar, Anna-Lena, Bolze, Florian, Jarick, Ivonne, Knoll, Nadja, Scherag, André, Reinehr, Thomas, Illig, Thomas, Grallert, Harald, Wichmann, Heinz-Erich, Wiegand, Susanna, Biebermann, Heike, Krude, Heiko, Fischer-Posovszky, Pamela, Rief, Winfried, Wabitsch, Martin, Klingenspor, Martin, Hebebrand, Johannes, Hinney, Anke
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544595/
https://ncbi.nlm.nih.gov/pubmed/23270367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-5-65
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