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Strategies for discovery and validation of methylated and hydroxymethylated DNA biomarkers
DNA methylation, consisting of the addition of a methyl group at the fifth-position of cytosine in a CpG dinucleotide, is one of the most well-studied epigenetic mechanisms in mammals with important functions in normal and disease biology. Disease-specific aberrant DNA methylation is a well-recogniz...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Blackwell Publishing Ltd
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3544446/ https://ncbi.nlm.nih.gov/pubmed/23342273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.22 |
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