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Energetics of Zinc-Mediated Interactions in the Allosteric Pathways of Metal Sensor Proteins

A metal-mediated interprotomer hydrogen bond has been implicated in the allosteric mechanism of DNA operator binding in several metal-sensing proteins. Using computational methods, we investigate the energetics of such zinc-mediated interactions in members of the ArsR/SmtB family of proteins (CzrA,...

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Autors principals: Chakravorty, Dhruva K., Parker, Trent M., Guerra, Alfredo J., Sherrill, C. David, Giedroc, David P., Merz, Kenneth M.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544337/
https://ncbi.nlm.nih.gov/pubmed/23214972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja309170g
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