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Hair Cell Replacement in Adult Mouse Utricles after Targeted Ablation of Hair Cells with Diphtheria Toxin

We developed a transgenic mouse to permit conditional and selective ablation of hair cells in the adult mouse utricle by inserting the human diphtheria toxin receptor (DTR) gene into the Pou4f3 gene, which encodes a hair cell-specific transcription factor. In adult wild-type mice, administration of...

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Hlavní autoři: Golub, Justin S., Tong, Ling, Ngyuen, Tot B., Hume, Cliff R., Palmiter, Richard D., Rubel, Edwin W., Stone, Jennifer S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544304/
https://ncbi.nlm.nih.gov/pubmed/23100430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1709-12.2012
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