Epigenetic-Genetic Interactions in the APC/WNT, RAS/RAF, and P53 Pathways in Colorectal Carcinoma

PURPOSE: Early events in colorectal tumorigenesis include mutation of the adenomatous polyposis coli (APC) gene and epigenetic hypermethylation with transcriptional silencing of the O(6)-methylguanine DNA methyltransferase (MGMT), human mut L homologue 1 (hMLH1), and P16/CDKN2A genes. Epigenetic alt...

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Main Authors: Suehiro, Yutaka, Wong, Chi Wai, Chirieac, Lucian R., Kondo, Yutaka, Shen, Lanlan, Webb, C. Renee, Chan, Yee Wai, Chan, Annie S.Y., Chan, Tsun Leung, Wu, Tsung-Teh, Rashid, Asif, Hamanaka, Yuichiro, Hinoda, Yuji, Shannon, Rhonda L., Wang, Xuemei, Morris, Jeffrey, Issa, Jean-Pierre J., Yuen, Siu Tsan, Leung, Suet Yi, Hamilton, Stanley R.
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544184/
https://ncbi.nlm.nih.gov/pubmed/18451217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-1802
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