MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension

Pulmonary hypertension (PH) results in pressure overload of the right ventricle (RV) of the heart, initiating pathological RV remodeling and ultimately leading to right heart failure. Substantial research indicates that signaling through the MAPK superfamily mediates pathological cardiac remodeling....

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Detalhes bibliográficos
Main Authors: Brown, R. Dale, Ambler, S. Kelly, Li, Min, Sullivan, Timothy M., Henry, Lauren N., Crossno, Joseph T., Long, Carlin S., Garrington, Timothy P., Stenmark, Kurt R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Signaling and Stress Response
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543664/
https://ncbi.nlm.nih.gov/pubmed/23125215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00158.2012
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