Cardiomyocyte-specific overexpression of an active form of Rac predisposes the heart to increased myocardial stunning and ischemia-reperfusion injury

The GTP-binding protein Rac regulates diverse cellular functions including activation of NADPH oxidase, a major source of superoxide production (O(2)(·−)). Rac1-mediated NADPH oxidase activation is increased after myocardial infarction (MI) and heart failure both in animals and humans; however, the...

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Hlavní autoři: Talukder, M. A. Hassan, Elnakish, Mohammad T., Yang, Fuchun, Nishijima, Yoshinori, Alhaj, Mazin A., Velayutham, Murugesan, Hassanain, Hamdy H., Zweier, Jay L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2013
Témata:
Signaling and Stress Response
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543663/
https://ncbi.nlm.nih.gov/pubmed/23161879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00367.2012
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