Hoxa9 Transduction Induces Hematopoietic Stem and Progenitor Cell Activity through Direct Down-Regulation of Geminin Protein

Hoxb4, a 3′-located Hox gene, enhances hematopoietic stem cell (HSC) activity, while a subset of 5′-located Hox genes is involved in hematopoiesis and leukemogenesis, and some of them are common translocation partners for Nucleoporin 98 (Nup98) in patients with leukemia. Although these Hox gene deri...

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Détails bibliographiques
Auteurs principaux: Ohno, Yoshinori, Yasunaga, Shin'ichiro, Janmohamed, Salima, Ohtsubo, Motoaki, Saeki, Keita, Kurogi, Toshiaki, Mihara, Keichiro, Iscove, Norman N., Takihara, Yoshihiro
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543444/
https://ncbi.nlm.nih.gov/pubmed/23326393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053161
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