Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential

Retrovirus-mediated transduction of Hoxb4 enhances hematopoietic stem cell (HSC) activity and enforced expression of Hoxb4 induces in vitro development of HSCs from differentiating mouse embryonic stem cells, but the underlying molecular mechanism remains unclear. We previously showed that the HSC a...

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Detalhes bibliográficos
Main Authors: Ohno, Yoshinori, Yasunaga, Shin'ichiro, Ohtsubo, Motoaki, Mori, Sayaka, Tsumura, Miyuki, Okada, Satoshi, Ohta, Tomohiko, Ohtani, Kiyoshi, Kobayashi, Masao, Takihara, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003101/
https://ncbi.nlm.nih.gov/pubmed/21098278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011054107
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