Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential

Retrovirus-mediated transduction of Hoxb4 enhances hematopoietic stem cell (HSC) activity and enforced expression of Hoxb4 induces in vitro development of HSCs from differentiating mouse embryonic stem cells, but the underlying molecular mechanism remains unclear. We previously showed that the HSC a...

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Bibliographic Details
Main Authors: Ohno, Yoshinori, Yasunaga, Shin'ichiro, Ohtsubo, Motoaki, Mori, Sayaka, Tsumura, Miyuki, Okada, Satoshi, Ohta, Tomohiko, Ohtani, Kiyoshi, Kobayashi, Masao, Takihara, Yoshihiro
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003101/
https://ncbi.nlm.nih.gov/pubmed/21098278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011054107
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