Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity

Polycomb-group (PcG) genes encode multimeric nuclear protein complexes, PcG complex 1 and 2. PcG complex 2 was proved to induce transcription repression and to further methylate histone H3 at lysine-27 (H3K27). Subsequently PcG complex 1 is recruited through recognition of methylated H3K27 and maint...

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Autori principali: Ohtsubo, Motoaki, Yasunaga, Shin'ichiro, Ohno, Yoshinori, Tsumura, Miyuki, Okada, Satoshi, Ishikawa, Nobutsune, Shirao, Kenichiro, Kikuchi, Akira, Nishitani, Hideo, Kobayashi, Masao, Takihara, Yoshihiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492514/
https://ncbi.nlm.nih.gov/pubmed/18650381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800672105
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