ATP Mediates NADPH Oxidase/ROS Generation and COX-2/PGE(2) Expression in A549 Cells: Role of P2 Receptor-Dependent STAT3 Activation

BACKGROUND: Up-regulation of cyclooxygenase (COX)-2 and its metabolite prostaglandin E(2) (PGE(2)) are frequently implicated in lung inflammation. Extracellular nucleotides, such as ATP have been shown to act via activation of P2 purinoceptors, leading to COX-2 expression in various inflammatory dis...

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Detalhes bibliográficos
Main Authors: Cheng, Shin-Ei, Lee, I-Ta, Lin, Chih-Chung, Wu, Wan-Ling, Hsiao, Li-Der, Yang, Chuen-Mao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543320/
https://ncbi.nlm.nih.gov/pubmed/23326583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054125
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