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Network-based assessment of the selectivity of metabolic drug targets in Plasmodium falciparum with respect to human liver metabolism

BACKGROUND: The search for new drug targets for antibiotics against Plasmodium falciparum, a major cause of human deaths, is a pressing scientific issue, as multiple resistance strains spread rapidly. Metabolic network-based analyses may help to identify those parasite’s essential enzymes whose homo...

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Main Authors: Bazzani, Susanna, Hoppe, Andreas, Holzhütter, Hermann-Georg
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543272/
https://ncbi.nlm.nih.gov/pubmed/22937810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-6-118
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