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Including metabolite concentrations into flux balance analysis: thermodynamic realizability as a constraint on flux distributions in metabolic networks

BACKGROUND: In recent years, constrained optimization – usually referred to as flux balance analysis (FBA) – has become a widely applied method for the computation of stationary fluxes in large-scale metabolic networks. The striking advantage of FBA as compared to kinetic modeling is that it basical...

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Hlavní autoři: Hoppe, Andreas, Hoffmann, Sabrina, Holzhütter, Hermann-Georg
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1903363/
https://ncbi.nlm.nih.gov/pubmed/17543097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-1-23
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