Ganglioside GD2-specific trifunctional surrogate antibody Surek demonstrates therapeutic activity in a mouse melanoma model

BACKGROUND: Trifunctional bispecific antibodies (trAb) are a special class of bispecific molecules recruiting and activating T cells and accessory immune cells simultaneously at the targeted tumor. The new trAb Ektomab that targets the melanoma-associated ganglioside antigen GD2 and the signaling mo...

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Hauptverfasser: Ruf, Peter, Schäfer, Beatrix, Eissler, Nina, Mocikat, Ralph, Hess, Juergen, Plöscher, Matthias, Wosch, Susanne, Suckstorff, Ivonne, Zehetmeier, Christine, Lindhofer, Horst
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543252/
https://ncbi.nlm.nih.gov/pubmed/23134699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-219
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