Structural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD and RING Finger Domains, 1) Protein

UHRF1 is an important epigenetic regulator connecting DNA methylation and histone methylations. UHRF1 is required for maintenance of DNA methylation through recruiting DNMT1 to DNA replication forks. Recent studies have shown that the plant homeodomain (PHD) of UHRF1 recognizes the N terminus of unm...

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Autori principali: Cheng, Jingdong, Yang, Yi, Fang, Jian, Xiao, Jianxiong, Zhu, Tingting, Chen, Fei, Wang, Ping, Li, Ze, Yang, Huirong, Xu, Yanhui
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543016/
https://ncbi.nlm.nih.gov/pubmed/23161542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415398
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