Physostigmine and Galanthamine Bind in the Presence of Agonist at the Canonical and Noncanonical Subunit Interfaces of a Nicotinic Acetylcholine Receptor

Galanthamine and physostigmine are clinically used cholinomimetics that both inhibit acetylcholinesterase and also interact directly with and potentiate nAChRs. As with most nAChR-positive allosteric modulators, the location and number of their binding site(s) within nAChRs are unknown. In this stud...

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Main Authors: Hamouda, Ayman K., Kimm, Tilia, Cohen, Jonathan B.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2013
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542985/
https://ncbi.nlm.nih.gov/pubmed/23303929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3483-12.2013
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