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A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation
We have identified a human cytomegalovirus cell-death suppressor, denoted vICA, encoded by the viral UL36 gene. vICA inhibits Fas-mediated apoptosis by binding to the pro-domain of caspase-8 and preventing its activation. vICA does not share significant sequence homology with FLIPs or other known su...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC35427/ https://ncbi.nlm.nih.gov/pubmed/11427719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.141108798 |
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