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A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation

We have identified a human cytomegalovirus cell-death suppressor, denoted vICA, encoded by the viral UL36 gene. vICA inhibits Fas-mediated apoptosis by binding to the pro-domain of caspase-8 and preventing its activation. vICA does not share significant sequence homology with FLIPs or other known su...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Skaletskaya, Anna, Bartle, Laura M., Chittenden, Thomas, McCormick, A. Louise, Mocarski, Edward S., Goldmacher, Victor S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC35427/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11427719/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.141108798
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