A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation

We have identified a human cytomegalovirus cell-death suppressor, denoted vICA, encoded by the viral UL36 gene. vICA inhibits Fas-mediated apoptosis by binding to the pro-domain of caspase-8 and preventing its activation. vICA does not share significant sequence homology with FLIPs or other known su...

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Detaylı Bibliyografya
Asıl Yazarlar: Skaletskaya, Anna, Bartle, Laura M., Chittenden, Thomas, McCormick, A. Louise, Mocarski, Edward S., Goldmacher, Victor S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2001
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC35427/
https://ncbi.nlm.nih.gov/pubmed/11427719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.141108798
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