Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells

Drugs that target the chief mediator of nuclear export, chromosome region maintenance 1 protein (CRM1) have potential as therapeutics for leukemia, but existing CRM1 inhibitors show variable potencies and a broad range of cytotoxic effects. Here, we report the structural analysis and antileukemic ac...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Etchin, J, Sun, Q, Kentsis, A, Farmer, A, Zhang, Z C, Sanda, T, Mansour, M R, Barcelo, C, McCauley, D, Kauffman, M, Shacham, S, Christie, A L, Kung, A L, Rodig, S J, Chook, Y M, Look, A T
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2013
Onderwerpen:
Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542631/
https://ncbi.nlm.nih.gov/pubmed/22847027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.219
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items