Sensitization to the mitochondrial pathway of apoptosis augments melanoma tumor cell responses to conventional chemotherapeutic regimens

Metastatic malignant melanoma is highly resistant to chemotherapy, and the average survival rate is under 1 year. The only FDA-approved conventional chemotherapy (i.e., dacarbazine) targets melanoma tumor cells by inducing a form of cell death referred to as apoptosis. However, dacarbazine exhibits...

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Detalhes bibliográficos
Main Authors: Anvekar, R A, Asciolla, J J, Lopez-Rivera, E, Floros, K V, Izadmehr, S, Elkholi, R, Belbin, G, Sikora, A G, Chipuk, J E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542597/
https://ncbi.nlm.nih.gov/pubmed/23152056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.161
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