Synthesis and Biological Evaluation of Indenoisoquinolines that Inhibit both Tyrosyl-DNA-Phosphodiesterase I (Tdp1) and Topoisomerase I (Top1)

Tyrosyl-DNA-phosphodiesterase I (Tdp1) plays a key role in the repair of damaged DNA resulting from the topoisomerase I (Top1) inhibitor camptothecin and a variety of other DNA-damaging anticancer agents. This report documents the design, synthesis, and evaluation of new indenoisoquinolines that are...

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Main Authors: Conda-Sheridan, Martin, Narasimha Reddy, P. V., Morrell, Andrew, Cobb, Brooklyn T., Marchand, Christophe, Agama, Keli, Chergui, Adel, Renaud, Amélie, Stephen, Andrew G., Pommier, Yves, Cushman, Mark
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542538/
https://ncbi.nlm.nih.gov/pubmed/23259865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3014458
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