Engineering a soluble high-affinity receptor domain that neutralizes staphylococcal enterotoxin C in rabbit models of disease

Superantigens (SAgs) are a class of immunostimulatory exotoxins that activate large numbers of T cells, leading to overproduction of cytokines and subsequent inflammatory reactions and systemic toxicity. Staphylococcal enterotoxin C (SEC), a SAg secreted by Staphylococcus aureus, has been implicated...

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Main Authors: Mattis, D.M., Spaulding, A.R., Chuang-Smith, O.N., Sundberg, E.J., Schlievert, P.M., Kranz, D.M.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542526/
https://ncbi.nlm.nih.gov/pubmed/23161916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzs094
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