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Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo
Cancer cells convert glucose preferentially to lactate even in the presence of oxygen (aerobic glycolysis–Warburg effect). New concepts in cancer treatment aim at inhibition of aerobic glycolysis. Pyruvate dehydrogenase converts pyruvate to acetylCoA thus preventing lactate formation. Therefore, the...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3542233/ https://ncbi.nlm.nih.gov/pubmed/22954700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.22003 |
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