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Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo
Cancer cells convert glucose preferentially to lactate even in the presence of oxygen (aerobic glycolysis–Warburg effect). New concepts in cancer treatment aim at inhibition of aerobic glycolysis. Pyruvate dehydrogenase converts pyruvate to acetylCoA thus preventing lactate formation. Therefore, the...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3542233/ https://ncbi.nlm.nih.gov/pubmed/22954700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.22003 |
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