A doxycycline-dependent human immunodeficiency virus type 1 replicates in vivo without inducing CD4(+) T-cell depletion

A novel genetic approach for the control of virus replication was used for the design of a conditionally replicating human immunodeficiency virus (HIV) variant, HIV-rtTA. HIV-rtTA gene expression and virus replication are strictly dependent on the presence of a non-toxic effector molecule, doxycycli...

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Dettagli Bibliografici
Autori principali: Legrand, Nicolas, van der Velden, Gisela J., Fang, Raphaël Ho Tsong, Douaisi, Marc, Weijer, Kees, Das, Atze T., Blom, Bianca, Uittenbogaart, Christel H., Berkhout, Ben, Centlivre, Mireille
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for General Microbiology 2012
Soggetti:
Animal
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542129/
https://ncbi.nlm.nih.gov/pubmed/22647372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.042796-0
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