Use of a Novel Chimeric Mouse Model with a Functionally Active Human Immune System To Study Human Immunodeficiency Virus Type 1 Infection

The goal of this study was to develop a small-animal model to study human immunodeficiency virus type 1 (HIV-1) pathogenesis in blood and primary and secondary lymphoid organs. Rag2(−/−)γ(c)(−/−) mice that are neonatally injected with human CD34(+) cells develop a functional human immune system (HIS...

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Autores principales: An, Dong Sung, Poon, Betty, Fang, Raphael Ho Tsong, Weijer, Kees, Blom, Bianca, Spits, Hergen, Chen, Irvin S. Y., Uittenbogaart, Christel H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2007
Materias:
Cellular Immunology, Antibodies, and Mediators of Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865603/
https://ncbi.nlm.nih.gov/pubmed/17314230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00403-06
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