Human CD5(+) Innate Lymphoid Cells Are Functionally Immature and Their Development from CD34(+) Progenitor Cells Is Regulated by Id2

Innate lymphoid cells (ILCs) have emerged as a key cell type involved in surveillance and maintenance of mucosal tissues. Mouse ILCs rely on the transcriptional regulator Inhibitor of DNA-binding protein 2 (Id2) for their development. Here, we show that Id2 also drives development of human ILC becau...

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Publicat a:Front Immunol
Autors principals: Nagasawa, Maho, Germar, Kristine, Blom, Bianca, Spits, Hergen
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583608/
https://ncbi.nlm.nih.gov/pubmed/28912776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01047
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