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Use of a Novel Chimeric Mouse Model with a Functionally Active Human Immune System To Study Human Immunodeficiency Virus Type 1 Infection
The goal of this study was to develop a small-animal model to study human immunodeficiency virus type 1 (HIV-1) pathogenesis in blood and primary and secondary lymphoid organs. Rag2(−/−)γ(c)(−/−) mice that are neonatally injected with human CD34(+) cells develop a functional human immune system (HIS...
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| Glavni autori: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2007
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1865603/ https://ncbi.nlm.nih.gov/pubmed/17314230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00403-06 |
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