Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier–dependent pathway

Small heat shock proteins (sHsps) bind destabilized proteins during cell stress and disease, but their physiological functions are less clear. We evaluated the impact of Hsp27, an sHsp expressed in airway epithelial cells, on the common protein misfolding mutant that is responsible for most cystic f...

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Bibliographic Details
Main Authors: Ahner, Annette, Gong, Xiaoyan, Schmidt, Bela Z., Peters, Kathryn W., Rabeh, Wael M., Thibodeau, Patrick H., Lukacs, Gergely L., Frizzell, Raymond A.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3541966/
https://ncbi.nlm.nih.gov/pubmed/23155000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-09-0678
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