Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier–dependent pathway

Small heat shock proteins (sHsps) bind destabilized proteins during cell stress and disease, but their physiological functions are less clear. We evaluated the impact of Hsp27, an sHsp expressed in airway epithelial cells, on the common protein misfolding mutant that is responsible for most cystic f...

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Hauptverfasser: Ahner, Annette, Gong, Xiaoyan, Schmidt, Bela Z., Peters, Kathryn W., Rabeh, Wael M., Thibodeau, Patrick H., Lukacs, Gergely L., Frizzell, Raymond A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3541966/
https://ncbi.nlm.nih.gov/pubmed/23155000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-09-0678
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