HPLC Method Determination of Isoliquiritin Apioside and Isoliquiritin in Rat Plasma for Application in Pharmacokinetic Study after an Oral Administration of Zhigancao Extract

A sensitive HPLC method was developed for the quantitative determination of isoliquiritin apioside (ILA) and isoliquiritin (IL) in rat plasma. After protein precipitation with acetonitrile, chloroform was used to separate lipid-soluble impurities from the plasma samples and remove acetonitrile. A ch...

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Detalhes bibliográficos
Main Authors: Yang, Yan-yun, Xu, Liang, Hao, Song-yao, Li, Yan, Zhang, Zhen-Qiu
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540785/
https://ncbi.nlm.nih.gov/pubmed/23365791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/364013
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