Carotid Atherosclerotic Plaque Matrix Metalloproteinase-12–Positive Macrophage Subpopulation Predicts Adverse Outcome After Endarterectomy

BACKGROUND: Matrix metalloproteinase-12 (MMP-12) promotes atherosclerosis in animal models. MMP-12 is expressed in only a subset of foam-cell macrophages (FCMs) in human plaques. We investigated whether the prevalence of this MMP-12–expressing subpopulation is a prognostic indicator of adverse outco...

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Detalhes bibliográficos
Main Authors: Scholtes, Vincent P. W., Johnson, Jason L., Jenkins, Nicholas, Sala-Newby, Graciela B., de Vries, Jean-Paul P. M., de Borst, Gert Jan, de Kleijn, Dominique P. V., Moll, Frans L., Pasterkamp, Gerard, Newby, Andrew C.
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540663/
https://ncbi.nlm.nih.gov/pubmed/23316311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.112.001040
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