Relationship of MMP-14 and TIMP-3 Expression with Macrophage Activation and Human Atherosclerotic Plaque Vulnerability

Matrix metalloproteinase-14 (MMP-14) promotes vulnerable plaque morphology in mice, whereas tissue inhibitor of metalloproteinases-3 (TIMP-3) overexpression is protective. MMP-14(hi)  TIMP-3(lo) rabbit foam cells are more invasive and more prone to apoptosis than MMP-14(lo)  TIMP-3(hi) cells. We inv...

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Detalhes bibliográficos
Main Authors: Johnson, Jason L., Jenkins, Nicholas P., Huang, Wei-Chun, Di Gregoli, Karina, Sala-Newby, Graciela B., Scholtes, Vincent P. W., Moll, Frans L., Pasterkamp, Gerard, Newby, Andrew C.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163186/
https://ncbi.nlm.nih.gov/pubmed/25301980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/276457
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