Fibroblast Growth Factor Receptor-Mediated Activation of AKT-β-Catenin-CBP Pathway Regulates Survival and Proliferation of Murine Hepatoblasts and Hepatic Tumor Initiating Stem Cells

Fibroblast Growth Factor (FGF)-10 promotes the proliferation and survival of murine hepatoblasts during early stages of hepatogenesis through a Wnt-β-catenin dependent pathway. To determine the mechanism by which this occurs, we expanded primary culture of hepatoblasts enriched for progenitor marker...

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Detalhes bibliográficos
Main Authors: Mavila, Nirmala, James, David, Utley, Sarah, Cu, Nguyen, Coblens, Orly, Mak, Katrina, Rountree, C. Bart, Kahn, Michael, Wang, Kasper S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540100/
https://ncbi.nlm.nih.gov/pubmed/23308088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050401
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