A Critical HA1 Neutralizing Domain of H5N1 Influenza in an Optimal Conformation Induces Strong Cross-Protection

The highly pathogenic avian influenza (HPAI) H5N1 viruses, especially the laboratory-generated H5N1 mutants, have demonstrated the potential to cross the species barrier and infect mammals and humans. Consequently, the design of an effective and safe anti-H5N1 vaccine is essential. We previously dem...

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Autores principales: Du, Lanying, Zhao, Guangyu, Sun, Shihui, Zhang, Xiujuan, Zhou, Xiaojun, Guo, Yan, Li, Ye, Zhou, Yusen, Jiang, Shibo
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539987/
https://ncbi.nlm.nih.gov/pubmed/23320093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053568
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