Dynamin-Related Protein 1 (DRP1)-Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension

RATIONALE: Pulmonary arterial hypertension (PAH) is a lethal syndrome characterized by pulmonary vascular obstruction due in part to pulmonary artery smooth muscle cell (PASMC) hyperproliferation. Mitochondrial fragmentation and normoxic activation of hypoxia-inducible factor-1α (HIF-1α) have been o...

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Detalhes bibliográficos
Main Authors: Marsboom, Glenn, Toth, Peter T, RyaN, John J., Hong, Zhigang, Wu, Xichen, Fang, Yong-Hu, Thenappan, Thenappan, Piao, Lin, Zhang, Hannah J, Pogoriler, Jennifer, Chen, Yimei, Morrow, Erik, Weir, E Kenneth, Rehman, Jalees, Archer, Stephen L
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539779/
https://ncbi.nlm.nih.gov/pubmed/22511751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.263848
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