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Epigenetic Regulation of Opioid-Induced Hyperalgesia, Dependence and Tolerance in Mice
Repeated administration of opioids such as morphine induces persistent behavioral changes including opioid-induced hyperalgesia (OIH), tolerance and physical dependence. In the current work we explored how the balance of histone acetyltransferase (HAT) vs. histone deacetylase (HDAC) might regulate t...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3539745/ https://ncbi.nlm.nih.gov/pubmed/23273833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2012.10.005 |
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